The oil painting "Portrait of Lost Smile" uses extreme realistic painting techniques to depict the portrait of the "Mona Lisa" composed of civil architectural bricks and stones. The "Mona Lisa" in history is the benchmark of civilization and Da Vinci's call for the most beautiful humanity, civilization and conscience of mankind! What runs counter to the "Mona Lisa" civilization is human indifference, numbness, fraud, wars, etc.... This work hopes that the "brick portrait" will arouse people's vigilance against the loss of humanity! Call for the true return of the Renaissance spirit!